What will decide outcome of north-west derby? Sky Sports experts give their verdict
Sky pundits Matt Le Tissier, Charlie Nicholas, Phil Thompson and Paul Merson reflect on key battles that could turn out to be decisive on Sunday.
Ex-Soton star Matt Le Tissier — Liverpool's attacking trio vs Mourinho's bus
"United's backline has to try and keep Liverpool's front three quiet for them to get anything out of the game and when you look at it on paper, that's going to be difficult. Jose Mourinho's not overly happy with any of his central defenders, he's chopped and changed it and getting any sort of consistency has been difficult."
"It wouldn't surprise me if he parked the bus again on Sunday as that's what Jose does when he feels like he's up against it. His default position is to defend and pinch a goal on the break. He has surprised us before with attacking line-ups but probably not in this game."
Ex-Gunner Charlie Nicholas — David de Gea's game vs our attacking capacity
"It's natural to look at it as Liverpool's attack versus United's defence, but the one guy who needs to have a good game is David de Gea. The key to Man Utd getting anything from this game is the form of the goalkeeper."
"He's not having the best season, he's made a few mistakes like the one against Arsenal, but he's only human. He's still one of the best in the world and he's saved them loads of points, including at Anfield before, and he needs to have a big game."
Ex-LFC defender Phil Thompson: Jose Mourinho's defence vs our attack
"It's probably United's defence against Liverpool's attack. Jose will want to have a go but he'll know he has to try and stay in the game. He may not park the bus but he'll set up to keep it tight and not fall too far behind in the early stages."
"Mourinho will know that if he comes away from Anfield with a point - regardless of how the game's played - that it'll be job done and a decent result. The fans will probably go back to Manchester happy enough with that."
Former Gunners midfielder Paul Merson: LFC front trio vs United's back four
"I can't see Man Utd having a go. This is where it disappoints me - it's Man Utd, going to Liverpool, come on have a go. The back four against Liverpool's front three is the whole battle. How can that back four, an average back four, keep out a majorly, majorly talented front three?"