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"Overnight he [Jadon Sancho] got sick, so he's not available," Erik ten Hag told MUTV.
"We will see [Lisandro Martinez and Christian Eriksen]. We will see how the game goes."
The Manchester United boss added: "I already said, we want to get many players with 90 minutes in their legs, but Martinez and Eriksen are not ready for that."
Along with Sancho, players like Raphael Varane, Aaron Wan-Bissaka, Eric Bailly, Phil Jones and Luke Shaw have not travelled to face Atletico Madrid.
However, the MEN understands they could be available to face Rayo Vallecano on Sunday.
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