Frenkie de Jong and Pedri are Barcelona's latest injury casualty. Both players are set to be out of action for at least one month.
On Monday, the club confirmed De Jong suffered a lateral ligament sprain in his right ankle while Pedri has a right quadriceps injury.
Barcelona face Mallorca in La Liga on Friday night before hosting Napoli in the second leg of their Champions League round-of-16 tie four days later.
The Catalans are already without Gavi for the remainder of the campaign after the Spaniard tore the anterior cruciate ligament in his right knee in November.
Here are the club's current midfield options: Christensen, Oriol Romeu, Gundogan, Fermín Lopez, Sergi Roberto, Marc Casado and Pau Prim.
Joao Felix is another option as an attacking midfield. However, he is unlikely to be deployed in that role.
Barcelona remain third in La Liga, one point behind Girona and eight behind league leaders Real Madrid.
Having been eliminated from the Copa del Rey and Spanish Supercopa, Europe is their one remaining hope of cup glory this season.
