Sky Sports' tactics expert backs Jose Mourinho to line-up with a 4-3-3 formation against Sarri's side as it would provide Man United with a real chance of ending Chelsea's unbeaten streak.
"We've spoken before about Lukaku and how he's been isolated at times," Higginbotham told Sky Sports News. "But the 4-3-3 has worked well for United, with Paul Pogba being able to advance as well.
"The three up front are able to play narrow. At times Martial and Rashford have gone into wide areas, probably more often than they would want to, leaving Lukaku isolated.
"But Luke Shaw, who has arguably been United's best player this season, and Ashley Young can go forward into those spaces with a 4-3-3 - and then you're creating a five vs four in United's favour against Chelsea's defence.
"With the full-backs advanced in the wide areas, you haven't just got Lukaku in the middle, you've now got at least two others with him."
While Marcus Rashford and Anthony Martial are tipped to help Romelu Lukaku being less isolated from his teammates, Nemanja Matic and Marouane Fellaini are believed to be crucial for Red Devils to prevent Chelsea from scoring after counterattacks.
"The reason United's full-backs are able to go forward is because they have the four covering," Higginbotham added. "The full-backs can go at the same time, the front three can play narrow, create three vs two, and Pogba has that free role going forward.
"If the play breaks down you have Matic and Fellaini comfortable going out wide to cover the full-backs."
